Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.gr
Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.gr
Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.gr
Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.grr
Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.gr
Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.gr
Ομοιοπαθητική Θεσσαλονίκη | omoiotherapeia.gr

MY HOMEOPATHIC TREATMENT

The first major feature of my Homeopathic Treatment is the Indivualization for Treatment Determination.This means that different people may have different pathogenic reasons,symptoms and syndromes even though the disease name is the same, so treatment strategies and formulas are different. So different treatment strategies will be used according to the different causative factors.

The other major principle is Totality for Treatment Determination.This means that in all Diseases the whole organism suffers,even if organ pathology is conventionally recognized in a certain organ or part of the body.So,treatment should be applied for both the diseased organ or part of the body and for the totality of all current sufferings all over the body.

 

Modern Homeopathy should care equally

for both the Patient and the Disease.

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Your First Appointment

Just after the booking of the Appointment and  before the Consultation,you are provided  via email with a printed Questionnaire,which must be completed.  It asks for:

    •Basic  contact details, including address, phone and mobile numbers, email address

    •A brief description  of  your current health problems

    •A brief reference to your past medical history

Try to complete the questionnaire well in advance of your appointment and bring to me at your consultation appointment

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MY HOMEOPATHIC CONSULTATION

The consultations take place in a comfortable, relaxed and friendly environment. The first time you come along for a consultation, I spend at least an hour talking through the specific symptoms,health conditions and/or disease(s) you have, obtaining all necessary details of your case history, including any relevant lab tests,medical records,etc that you might already have. During this time you will have a unique opportunity to talk in detail with me about these ailments.Any questions I ask will help me to get a good understanding of your physical and/or emotional problems.

 

Once Homeopathic treatment has started, follow-up appointments take place once every 4-8 weeks( usually every 6 weeks). During follow up appointments, it is assessed how you are getting on with the homeopathic remedies prescribed, the progress you have made according to homeopathic principles and any indicated extension of the homeopathic case taking is added and included. Further homeopathic medication is prescribed for you based on this evaluation.The whole process is about reviewing , re-formulating and proceeding the planned homeopathic treatment

 

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Homeopathic Expertise and Style

 

CLINICAL HOMEOPATHY HAS  ALL THE REQUIRED MEDICAL SCIENTIFIC EVIDENCE

 

There are literally hundreds of high quality, published basic science, pre-clinical and clinical studies showing that homeopathy works. If someone searches in PubMed, a renowned Medical Literature Record, with the key word “homeopathy”, about 5.000 of publications in medical journals appear; therefore no one may claim that there is not accessible and reliable medical information or that there is no place for Homeopathy in the space of Scientific Evidence.

Homeopathic Remedies are carriers of pharmacological information biophysically imprinted on water molecules contained in your homeopathic "sugar pills or tablets".This information is reminiscent of the digital information of computers' technology,with which modern societies are too familiar.

 

In the UK it is estimated that Homeopathy is growing 20% each year; it has been enrolled in the National Health System through an Act of Parliament from 1950 to the present.

The Swiss government has a long and widely-respected history of neutrality, and therefore, reports from this government on controversial subjects need to be taken more seriously than other reports from countries that are more strongly influenced by present economic and political constituencies. When one considers that two of the top five largest drug companies in the world have their headquarters in Switzerland, one might assume that this country would have a heavy interest in and bias toward conventional medicine, but such assumptions would be wrong.

In late 2011, the Swiss government's report on homeopathic medicine represents the most comprehensive evaluation of homeopathic medicine ever written by a government and was just published in book form in English. This breakthrough report affirmed that homeopathic treatment is both effective and cost-effective and that homeopathic treatment should be reimbursed by Switzerland's national health insurance program.

 

There are literally hundreds of high quality, published basic science, pre-clinical and clinical studies showing that homeopathy works. If someone searches in PubMed, a renowned Medical Literature Record, with the key word “homeopathy”, about 5.000 of publications in medical journals appear; therefore no one may claim that there is not accessible and reliable medical information or that there is no place for Homeopathy in the space of Scientific Evidence.

Homeopathic Remedies are carriers of pharmacological information biophysically imprinted on water molecules contained in your homeopathic "sugar pills or tablets".This information is reminiscent of the digital information of computers' technology,with which modern societies are too familiar.

In the UK it is estimated that Homeopathy is growing 20% each year; it has been enrolled in the National Health System through an Act of Parliament from 1950 to the present.

The Swiss government has a long and widely-respected history of neutrality, and therefore, reports from this government on controversial subjects need to be taken more seriously than other reports from countries that are more strongly influenced by present economic and political constituencies. When one considers that two of the top five largest drug companies in the world have their headquarters in Switzerland, one might assume that this country would have a heavy interest in and bias toward conventional medicine, but such assumptions would be wrong.

In late 2011, the Swiss government's report on homeopathic medicine represents the most comprehensive evaluation of homeopathic medicine ever written by a government and was just published in book form in English. This breakthrough report affirmed that homeopathic treatment is both effective and cost-effective and that homeopathic treatment should be reimbursed by S The

The Swiss government's inquiry into homeopathy and complementary and alternative (CAM) treatments resulted from the high demand and widespread use of alternatives to conventional medicine in Switzerland, not only from consumers but from physicians as well. Approximately half of the Swiss population have used CAM treatments and value them. Further, about half of Swiss physicians consider CAM treatments to be effective. Perhaps most significantly, 85 percent of the Swiss population wants CAM therapies to be a part of their country's health insurance program. It is therefore not surprising that more than 50 percent of the Swiss population surveyed prefer a hospital that provides CAM treatments rather to one that is limited to conventional medical care.

Beginning in 1998, the government of Switzerland decided to broaden its national health insurance to include certain complementary and alternative medicines, including homeopathic medicine, traditional Chinese medicine, herbal medicine, anthroposophic medicine, and neural therapy. This reimbursement was provisional while the Swiss government commissioned an extensive study on these treatments to determine if they were effective and cost-effective. The provisional reimbursement for these alternative treatments ended in 2005, but as a result of this new study, the Swiss government's health insurance program once again began to reimburse for homeopathy and selective alternative treatments. In fact, as a result of a national referendum in which more than two-thirds of voters supported the inclusion of homeopathic and select alternative medicines in Switzerland's national health care insurance program, the field of complementary and alternative medicine has become a part of this government's constitution.

 

Evidence of Homeopathy in Medical Literature

You will find below only an actually small section of the scientific evidence and validation of homeopathy. Scientific research into homeopathy started in the 70s in mainland Europe, mainly in Germany, France and Switzerland, where this type of medicine is common place. At the time, public health agencies wanted to ensure that homeopathic remedies were assessed in the same way as chemical drugs. The results were so positive that several pharmaceutical companies invested in homeopathy.Nowadays, developing countries (primarily India, Russia, China, Cuba, South Africa and Brazil) have also become major centres of homeopathic research. The overall low-cost and easy availability of homeopathic products have convinced these countries to invest heavily into homoeopathy.

Finally, the USA has become a late entrant. Homeopathy seems to regain popularity among the American medical group, and several University medical centres have research on homeopathy, or “ultra-dilution” as it is called in some scientific quarters.

 

Certain indicative published articles in peer-reviewed medical journals follow:

Positive effects of homeopathic solutions on human white blood cells in inflammation

Mar. 2005 – New Scientist  – Dr Ennis is a renowned pharmacologist at Queen’s University, Belfast. Her team conducted the effects of ultra-diluted solutions of histamine on human white blood cells involved in inflammation. The study shows a positive effect of the homeopathic solution. Dr Ennis concluded that “We are unable to explain our findings and are reporting them to encourage others to investigate this phenomenon.”

 

Antiviral Activity of Engystol Homeopathic Preparation

2005, The Journal of Alternative & Complementary Medicine, vol. 11, No. 5, 855-862 (IAH), Oberbaum, M et al – compared to placebo, Engystol inhibited in cell cultures (in vitro study) the viral proliferation of different viruses: HSV-1 was inhibited by almost 80%, Adeno-5 Virus by 60% and the respiratory scyncitial virus (RSV) by 40%. Less inhibition occurred with the rhinovirus V14 and the flu virus (influenza A).

 

Inhibition of IL-1Beta and TNF Alpha Secretion from Resting and Activated Human Immunocytesby Homeopathic Medication Traumeel

 

(2004, Clinical & Developmental Immunology; 11(2): 143-149 (IAH), PorozoV S, Cahalon L, Weiser M, Branski D, Lider O, Oberbaum M) – This research showed that the homeopathic medication Traumeel inhibits the secretion of two cortisol-production inhibitors, and this allows inflammation regulation. This resulted in a strong reduction of the clinical symptoms of inflamed patients using Traumeel.

 

Behandlung der Gonarthrose Der Allgermeinarzt

2003,, 25 (4): 261-64, Birnesser H. Klein P, Weiser M – In a prospective, referenced-controlled multicentre cohort study of 592 patients suffering from mild to moderate osteoarthritis of the knee, the efficacy of Zeel homeopathic tablets was tested in comparison to Celebrex and Vioxx, two chemical drugs. In global assessments of tolerability, more than 90% of the patients in the Zeel group but only 74% of the chemical drugs’ groups reported “very good tolerability”. Parameters such as stiffness, pain and functionality of the knee were measured using the validated WOMAC Osteoarthritis Index. Overall results of the study revealed that with regard to efficacy, treatment with Zeel tablets is equivalent to therapy with chemical drugs.

 

Hepeel Homeopathic Remedy and its constituent plant tinctures – antioxidative, antiproliferative and biochemical effects in HepG2 cells

 

2003, Arzneimittel-Forschung / Drug Research, 53, No. 12 823-830 (IAH) Rob Gebhardt – The study was in-vitro. It showed that none of the Hepeel constituents and combinations had cytotoxic effects, and allowed reduction of MDA-production (Carduus Marianus was however most effective). The D4 homeopathic potency (or dilution) was the most effective, with reduction of over 70%.

 

Therapeutic use of homeopathic complex product – Lymphomyosot

1990, Biological Therapy, Volume VIII, No. 3 (IAH) –This is the result of a multicentre use observation study on 3,512 patients with lymph pathology (diverse, from lymphedema to tonsillitis). Overall, the study showed in practice good therapeutic results, especially in inflammatory conditions, where remarkable results were seen.

 

The Structure Of Liquid Water; Novel Insights From Materials Research; Potential Relevance To Homeopathy

Dec. 2007, Material Research Innovation. A scientific study about the molecular properties of a water by Rustum Roy (a well renowned research professor of materials at Arizona State University). It was accepted and published in September 2005. It is quoted by the Guardian on an article about homeopathy “Homeophobia’ must not be tolerated”.

 

Homeopathic Remedies to Kill Breast Cancer Cells

 

(Feb 2010 – “” CMA e-Newsletter) – This reports a study from the University of Texas’ Integrative Medicine Programme Unit, showing positive effects of homeopathic remedies (or “ultra-diluted” as they are called by many scientists) on breast cancer cells. The study was named “Cytotoxic effects of ultra-diluted remedies on breast cancer cells”, and a link can be found below. The body of the study clearly states the homeopathic products used.

 

Germany – Eczema – homeopathy as good as conventional treatment, 2006, Daily Mail.

The Daily Mail reported the results of a comparative cohort study of homoeopathic & conventional treatment of children with eczema. This was done by the Institute for Social Medicine, Epidemiology and Health Economics of the Charité University Medical Centre Berlin (D-10098 Berlin, Germany). The results were positive for homeopathy compared to conventional medicine, in both effectiveness and value-for-money. The study can now be purchased here: www.sciencedirect.com

 

A study of the effect of decimal and centesimal dilution of arsenic on retention and mobilization of arsenic in rats

(June 1987, JC Cazin et al., Human Toxicology). This is a research about artificially arsenic poisoned rated, and the impact of homeopathic remedies on the doses of intoxication and urinal excretion of arsenic. Dilutions above the number of Avogrado of arsenic had a significant impact according to this study.

 

Influence of homeopathic drug preparations on the phagocytosis capability of granulocytes, in vitro test and controlled single blind studies

Reprint from Arzneimittel-Forschung und Drug research; 1986 36(9): 1421-5 (IAH): Wagner H et al. . Important research was done by Prof. Wagner from the University of Munich (Germany). In this, he found that after 5 days of successive administration, the homeopathic drug Engystol increased the activity of granulocytes by 33.5%, the Gripp-Heel homeopathic drug achieved 30.8% and the two in combination achieved 40%. Echinacea, a known immunostimulator also had a positive effect at a 1/10.000 dilution.

 

Efficiency of tick biotherapic on the control of infestation by Rhipicephalus microplus in Dutch dairy cows

(Zilda Cristiani Gazim, Fabiana Borges Padilha Ferreira, Aristeu Vieira da Silva, Kelly Cristina Bolognese, Ewerton Merlin, Valdeci Messa, & al.). A study from the University Paranaense – UNIPAR, Umuarana, Brazil showing the positive results on infecting-cow ticks. A group of Dutch cows were divided in 2 groups: one group received 100g/day of mineral salt supplement impregnated with tick biotherapic 12CH for 6 months, and then in alternate days with tick biotherapic 30CH to complete 28 months of treatment; the control group received only the mineral salt supplement.

 

Use of Homeopathy for Dengue Fever by the Indian Public Health System

Hindu Times, 2 Dec. 12. This newspaper reported a successful governmental campaign of distribution of the homeopathic product ‘Eupatorium Perfoliatum,’ for dengue prevention. The treatment was conducted at six places in Karaikudi and the medicine supplied to 16,000 persons.

 

Nov 2010 – Homoeopathic Immunisation Against Leptospirosis in Cuba

A ground-breaking project with the successful use of homoeo-prophylaxis (= prevention using homeopathy) in Cuba involving millions of people. The target disease, Leptospirosis, is endemic there and the study demonstrated the effectiveness of this safe and low cost method.

 

Jul 2010 – Nobel laureate gives homeopathy a boost, The Australian

Professor Luc Montagnier, French virologist & winner of the Nobel prize of medicine is currently focusing his research in the low-frequency emission of homeopathic products (also called “ultra-dilutions” as they are so diluted that there is no physical remains of the primary substance). This has been widely reported in Europe and in the US.

Potential of the homeopathic remedy Arnica 30c (NOTE: “beyond Avogadro’s number”) to reduce DNA damage

This study examines to what degree an ultra-highly diluted homeopathic remedy, Arnica Montana 30C (AM-30C), used in the treatment of shock and injury, can modulate the expression of nucleotide excision repair genes in Escherichia coli exposed to ultraviolet (UV) irradiation. AM-30C helped repair the DNA damage through up-regulation of repair genes and also ameliorated the oxidative stress through the reduction of ROS generation and suitable modulation of anti-oxidative stress enzymes.

 

Strychnos nux-vomica extract and its ultra-high dilution reduce voluntary ethanol intake in rats

The scientists wanted to see whether Strychnos nux-vomica extract (mother tincture [MT]), its potency Nux 30c, and its principal alkaloid, strychnine, could reduce voluntary ethanol intake in rats. To analyze the solution structure of Nux MT, Nux 30c, 90% ethanol, and ethanol 30c by means of electronic (ES) and nuclear nuclear magnetic resonance (NMR) spectra. The study concluded that Nux MT and Nux 30c could reduce ethanol intake in rats. The altered solution structure of Nux 30c is thought to mimic Nux MT and produce ethanol aversion in rats. Check the following site for more information: ncbi.nlm.nih.gov

Potentized Mercuric chloride and Nux vomica facilitate water permeability in erythrocytes of a fresh-water catfish Clarius batrachus under acute ethanol intoxication

The primary biomolecular target of a homeopathic potency is unknown. If it is a plasma membrane protein such as water-channel protein, the drug would alter water permeation in cells. Therefore, the objective is to see if potentized homeopathic drugs like Mercuric chloride 30c and Nux vomica 30c could alter permeation of water through the erythrocytes of a fresh water fish under acute ethanol intoxication. The conclusion was that red blood cells (RBCs) from ethanol-injected fish permeated more water than those from normal fish. Water permeation was enhanced with Merc cor 30c and Nux vom 30c. RBCs from fish pretreated with Nux vom 30c imbibed more water in in vitro treatments than those from fish pretreated with Ethanol 30c. Check the following site for more information: ncbi.nlm.nih.gov

 

Heparin-binding epidermal growth factor expression in KATO-III cells after Helicobacter pylori stimulation under the influence of strychnos Nux vomica and Calendula Officinalis

Baseline expression and stimulation were similar to previous experiments, addition of Nux vomica 10c and Calendula officinalis 10c in a 43% ethanolic solution led to a significant reduction of H. pylori induced increase in gene expression of HB-EGF (reduced to 53.12+/-0.95% and 75.32+/-1.16% vs. control; p<0.05), respectively. Nux vomica 12c reduced HB-EGF gene expression even in dilutions beyond Avogadro’s number (55.77+/-1.09%; p<0.05). Nux vomica 12c in a 21.5% ethanol showed a smaller effect (71.80+/-3.91%, p<0.05). This effect was only be observed when the drugs were primarily prepared in ethanol, not in aqueous solutions. The data suggest that both drugs prepared in ethanolic solution are potent inhibitors of H. pylori induced gene expression.

 

Homeopathic treatment for peripheral nerve regeneration: an experimental study in a rat sciatic nerve transection model

Researchers from the Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, in Iran, the Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Canada and the R&D Division, Azar Masoon Vaccine, Biological and Pharmaceuticals Distribution Company, Urmia, Iran have undertaken research (RCT) that proves that the homeopathic remedy, Hypericum improves the functional recovery of peripheral nerve regeneration. The research, published in the journal ‘Homeopathy’ was undertaken on rats and showed that, in the group who were treated with Hypericum, there was a faster and better recovery of regenerated axons and gastrocnemius muscle mass was significantly greater. The study can be purchased on Science Direct.

 

Two homeopathic remedies used intermittently provide additional protective effects against hepatotoxicity Induced by carcinogens in mice

 

Author: Nandini Bhattacharjee, Anisur Rahman Khuda-Bukhsh , Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, India. See Science Direct website to purchase the study.

Homeopathic treatment for chronic disease: a 6-year University-Hospital outpatient observational study

 

2005 – Spence DS, Thompson EA – The Journal of Alternative and Complementary Medicine, Vol. 11 #5, (ARH-Aut11). This scientific observational study of 6,544 patients suffering from a broad range of chronic conditions, including asthma, arthritis, chronic fatigue and so on, over 23,000 consultations, showed that 70.2% reported positive health changes. For the children in the group, the positive health changes were over 80%.

 

CAM Project, Northern Ireland, Mc Dade D – 2008 Evaluation, (ARH-Aut11)

This project, which included homeopathy referred by GPs, was commissioned by the Department of Health, Social Services and Public Safety. The overall patient experience showed a significant level of health gain for the vast majority of patients.

Patients’ assessment of effectiveness of homeopathic care in Norway

 

January 2005, Steinsbekk A, Homeopathy, Vol. 94, Issue 1  (ARH-Aut11). Over 70% of patients visiting Norwegian homeopaths reported a meaningful improvement of their main complaint 6 months after the initial consultation.

 

Audit of outcome in 829 consecutive patients treated with homeopathic medicine”, Sevar R, British Homeopathic Journal, Oct. 2000, Vol 89 No 4, (ARH-Aut11)

A study of patients treated with homeopathy after conventional treatment had been unsatisfactory or contraindicated, showed that 61% of them had a substantial improvement with homeopathy.

 

Treatment of acute childhood diarrhoea with homeopathy – randomized clinical trial in Nicaragua”, 1994,  Jacobs J, Pediatrics, 93 – 719-725, (ARH-Aut11)

The trial involved 81 children aged between 6 months and 5 years in a randomized, double-blind trial of placebo versus homeopathy. The group treated with homeopathy had a statistically significant decreased in the duration of diarrhoea.

 

 

 

Acute Childhood Diarrhoea – replication of the 1994 trial carried out in Nicaragua – Nepal

Jacobs J, Jimenez M, Malthouse S, Chapman E…., Journal of Alternative and Complementary Medicine, 6, 2000, 131-139, (ARH-Aut11) – On a replication of the 1994 study (shown above), 116 Nepalese children were treated and the result showed significant improvement in the condition in comparison to the placebo-group.

 

Report on NHS practice-based homeopathy: analysis of effectiveness and cost of homeopathic treatment within a GP practice at St. Margaret’s Surgery, Bradford on Avon, Wilts

Christie EA, Ward AT, (ARH-Aut. 11) – A survey of homeopathic treatment within a GP homeopathic practice showed that 72% of patients showed improvement.

 

Homeopathy and Respiratory allergies: a series of 147 cases

Colin P – ‘Homeopathy’ – 95, 68-72 (ARH-Aut11). Reilly and colleagues conducted a series of trials in patients with hayfever, asthma and rhinitis. The results demonstrate a significant a reproducible difference between the placebo and the homeopathic groups.

 

Medical Study shows positive effect of homeopathic remedies on bovine sperm mitochondria activity

This study was conducted by the German Pharmaceutical company Heel to evaluate the effect of two homeopathic complexes Ubichinon compositum and Coenzyme compositum on bovine sperm mitochondrial activity. The tested homeopathic complex medicines stimulate the mitochondrial activity of bovine sperm without effects on their viability, acrosomal integrity or chromatin structure. The possibility that this translates into improved fertilization capacity in artificial insemination should investigated.

 

Positive Double Blind Study on Homeopathic Therapies for the side effects of chemotherapy

The prestigious International Journal of the Cancer Society published in August 2001 the results of a double blind pilot study, which studied the effects of antihomotoxical therapy in the treatment of chemotherapy induced stomatitis in children. Antihomotoxical therapy is a branch of Clinical Homeopathy, popularised by the German homeopathic pharmacy, Heel AG. Please contact the pharmaceutical company or the Journal for more information.

 

 

Double-blind controlled clinical study on arthritis patients show positive effects of homeopathic remedies compared to chemical painkiller

Published in the Journal of Biomedical Therapy (Fall 2000,: 10-1, Comparison of the efficacy and tolerance of Zeel Comp. and diclofenac for the treatment of gonarthrosis). In a multi-centre randomised, double-blind, controlled clinical study of 121 patients with mild to moderate arthritis of the knee, Zeel homeopathic tablets and the chemical drug Diclofenac were each administered. The validated, disease-specific, self-administered WOMAC Osteoarthritis Index showed treatment with Zeel tablets to be quivalent to Diclofenac therapy with regard to efficacy.

 

Decreased intensity of Japanese encephalitis virus infection in chorioallantoic membrane under Influence of ultra-diluted Belladonna extract

A 2010 Indian study, sponsored by the Ministry of Health, and published in the prestigious American Journal of Infectious Diseases (6 (2): 24-28, 2010 ISSN 1553-6203). It shows that ultra-diluted belladonna could inhibit JE virus infection.  Ultra-diluted is a term used by some medical scientists who prefer not to use “homeopathic”.

 

Positive Results of a Homeopathic Drug Monitoring Study for Hayfever (allergic rhinitis)

(1994, Frase W. Weiser M. Antihomotoxic Treatment of Hayfever. Biological Therapy, Vol. 8, No. 3: 91-96). In a drug monitoring study, concomitant administration of Heel’s Luffa homeopathic complex preparation (nasal spray and tablets) was rated by over 70% of 1,090 hay fever patients as either “good” or “very good” therapy. A similar 6-week study in 1999 with 146 patients suffering from seasonal allergic rhinitis showed significant and lasting improvement, equivalent to that of cromolyn sodium. a chemical medication.

 

Successful use of homeopathy in a mass immunisation campaign in Cuba

A positive Cuban medical experiment was made public in January 2009. It was a large scale project of using homeopathy to reduce the effect of an epidemic Leptospirosis outbreak after tropical flooding). This is a remarkable event in a country that has very little access to medical chemical drugs, and has invested heavily in alternative medical approaches.  This event was widely reported on alternative health sites and also in the medical world (such as the US Vaccine Convention in 2010), but had unfortunately no coverage in the main English-speaking media.

 

Homeopathic remedies show positive effects on brain activity

The San Francisco Chronicle reported in May 2011 a medical study from the Justus Liebig University in Germany that demonstrates to positive effects on brain waves as recorded by electroencephalogram (EEG), from the ingestion of homeopathic remedies. This is yet another scientific study from Germany, a country well in advance in terms integrated medicine.

 

Positive in-vitro study of a homeopathic product on HSV, RSV and Influenza Type A Viruses

Published in Nov. 2001 in Komplementarmedizin – Naturheilkunde, 2001 (8: 207-212 IAH – Antiviral action of Homeopathic Medication). The homeopathic product called Euphorbium Compositum has been tested in this in-vitro study of Metelmann and Glatthaar-Sallmuller. Three groups of plaques were created with cultured test cells. The first was infected with the virus and was added the homeopathic substance. The second was infected as well but a saline solution was added (placebo), and the third one was a negatice control (saline solution only). The inhibition on the proliferation was positive for the homeopathic preparation, at 35% for the HSV-1 virus, 35% for the RSV virus and 15% for Influenza Type A virus.

 

Effectiveness of Arnica 7C and Hypericum 15C for people suffering from dental neuralgia

Albertini H, Goldberg W, Sanguy B, Toulza CL. Homeopathic treatment of dental neuralgia by Arnica and Hypericum. Journal of the American Institute of Homeopathy, 1985, 3, 126-129. Carried out at the Faculty of Medicine of Marseilles, placebo controlled study, twice as many people on homeopathy responded positively compared t the placebo group.

 

Effects of the homeopathic preparation Engystol on interferon-gamma production by human T-lymphocytes

 

Enbergs H., Immunol Invest. 2006, 35, 1, 19-27. In one of the few experiments carried out in this area to date, researchers conducting this study collected T-lymphocytes from 30 healthy human volunteers to investigate the ability or otherwise of a homeopathic combination product to increase the production of interferon-gamma from these cells. After exposure to various concentrations of this combination, when compared to control cells, interferon-gamma producing cell levels were increased by a means of 20.9% to over 24% with no dose-dependence of the effect at the concentrations tested.

 

Double blind placebo controlled trial, 50 children suffering from post-operative pain and agitation

Alibeu JP, Jobert J. Aconite in Post-Operative Pain and Agitation in Children, Pediatrie, 1990, 45, 7-8, 465-6. Effects of Aconite were significantly better than placebo.

 

Treatment of inflammatory diseases of the upper respiratory tract – comparison of a homeopathic complex remedy with the chemical drug xylometazoline

Ammerschlager H., Klein P., Weiser M., Oberbaum M., Forsch Komplementarmed Klass Naturheilkd. 2005, Feb, 12, 1,:24-31. In a multi-centre, controlled, cohort study, 739 people suffering from rhinitis or sinusitis were given either xylometazoline (a drug commonly used for nasal congestion, sinusitis and hay fever) or a homeopathic combination. Both forms of therapy provided similarly effective results but the homeopathic treatment has significantly less side-effects.

 

The effect of Gencydo homeopathic injections on hayfever symptoms: a therapeutic causality report on homeopathy

Baars EW, De Bruin A. J Altern. Complement Med. 2005 Oct, 11, 5, 863-9. In this study, 13 Dutch medical practitioners submitted patients (who between them had a mean history of hayfever of 9 years), for therapy involving injections of a combination homeopathic product. All but 1 patient were given the medication before the onset of the hayfever season and all were given it during the hayfever season. Of these 13, during the course of the trial 9 people found no increase in nasal and non-nasal hayfever symptoms when the hayfever season began or during it and only 1 of the 13 felt compelled to use conventional hayfever medication.

 

Zinc: Immunoglobin relationship in patients with cirrhosis of the liver before and after treatment with Zincum Metallicum 5CH

 Baduluci S, Chirulescu Z, Chirila P, Rosca A. – International Research Group on Very Low Dose and High Dilution Effects, 1993 Giri Meeting, British Homoeopathic Journal, April, 1994, 83, 84-100. 10 people suffering from Zinc deficiency as determined by atomic absorption spectrophotemetry were treated with Zincum metallicum 5CH. Analysis following this treatment showed a substantial improvement in zinc levels.

 

Can homeopathy bring additional benefits to thalassemic patients on hydroxyurea therapy? Encouraging results of a preliminary study

Banerjee A, Chakrabarty SB, Karmakar SR, Chakrabarty A, Biswas SJ, Haque S, Das D, Paul S, Mandal B, Naoual B, Belon P, Khuda-Bukhsh AR. Evidence Based Complementary and Alternative Medicine. 2010 March; 7(1): 129–136. In this observational study, 38 people suffering from thalassaemia who were taking hydroxyurea, were allowed to continue their use of hydroxyurea but were given one of several homeopathic medicines. The effects of this additional treatment were compared to the outcomes of another 38 people suffering from thalassaemia who used hydroxyurea alone, assessed immediately before and at 3 months after starting the homeopathic treatment. Of a range of haematological and clinical parameters, those people using the combined treatment showed an increase in levels of foetal haemoglobin over those on hydroxyurea alone, along with a reduction in serum ferritin. Where splenomegaly was present, a significant reduction in this was noted in those on the combined therapy and this group also noted an improvement in general health with a longer period allowed between blood transfusions.

 

Homoeopathy for post-operative ileus: a meta-analysis

 

Barnes J., Resch K-L., Ernst E. Journal of Clinical Gastroenterology, 1997, Dec, 25, 4, 628- 633. 7 separate trials examining the effects of homoeopathic treatment for post-operative ileus after abdominal or gynaecological surgery when compared with placebo, specifically, for the time to first flatus after surgery. Subsequent analysis showed that homoeopathy provided superior results to placebo.

 

Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo

Bell IR, Lewis DA, Brooks AJ, Schwartz GE, Lewis SE, Walsh BT, Baldwin CM. Rheumatology (Oxford). 2004 May;43(5):577-82. 53 people suffering from fibromyalgia took part in this trial, comparing individualised homoeopathic treatment to placebo. The levels of tender points and tender point pain as well as quality of life, mood and general health were assessed by the practitioners and subjects involved in the trial. 3 months after commencing treatment, all parameters were found to be improved by the use of homoeopathy when compared to placebo.

 

Can administration of potentized homeopathic remedy, Arsenicum album, alter antinuclear antibody (ANA) titre in people living in high-risk arsenic contaminated areas?

 

Belon P, Banerjee P, Choudhury SC, Banerjee A, Biswas SJ, et al. I. A correlation with certain haematological parameters. Evid Based Complement Alternat Med. 2006 Mar; 3 (1):99-107. Selected inhabitants of arsenic affected villages in India’s West Bengal were randomly assigned to receive either Arsenicum album or placebo. After 2 months of administration, it was found that not only did the remedy provide superior results in reducing the ANA titre, it also caused a correction of arsenic-induced haematological changes such as total count of red blood cells and white blood cells, packed cell volume, haemoglobin content, erythrocyte sedimentation rate and blood sugar level.

 

Homeopathic remedy for arsenic toxicity

Belon P, Banerjee A, Karmakar SR, et al.  Evidence-based findings from a randomized placebo-controlled double blind human trial. Sci Total Environ. 2007 Jul 10. This was a pilot study carried out on 25 people from an Indian village where arsenic contamination was endemic and 18 people from another Indian village without arsenic contamination. The use of Arsenicum album 30C had a beneficial effect on the selected biomarkers. It was also found to improve the appetite and general health of those people who previously exhibited signs and symptoms of arsenic toxicity.

 

Treatment of pain due to unwanted lactation with a homeopathic preparation given in the immediate post-partum period

 

Berrebi A, Parant O, Ferval F, Thene M, Ayoubi JM, Connan L, Belon P. Gynecology, Obstetrics and Biological Reproduction, 2001, June, 30, 4, 353-7. 71 post- parturient women who were unwilling or unable to breast feed were divided into 2 groups, one being given a placebo and the other group being given a mixture of Apis 9C and Bryonia 9C, to determine the effects of either on lactation pain. A significant improvement was noted in the group using the mixture, when compared to those in the placebo group.

 

Homeopathic treatment of anal fissures using Nitricum Acidum

Bignamini M, Saruggia M, Sansonetti G. – Berlin Journal on Research in Homoeopathy, 1, 4/5, 286-287, December 1991. Patients using Nitricum acidum 9C once daily in a double blind placebo controlled trial found subjective relief with the medicine over the placebo.

 

Safety and cost-effectiveness of homeopathy in general practice – summarized health technology assessment

Bornhoft G, Wolf U, Ammon K, et al. Forsch Komplementarmed. 2006;13 Suppl 2:19-29. This was an effectiveness and safety study on homeopathy carried out for the Swiss Federal Office for Public Health. The conclusion was in favour of a therapeutic benefit from homeopathic intervention. In addition, it was stated by the authors of the study that, “…effectiveness of homeopathy can be supported by clinical evidence and professional and adequate application be regarded as safe. “

Homoeopathic treatment of migraine

Brigo B, Serpelloni G, , Berlin Journal on Research in Homoeopathy, 1, 2, March, 1991, 98-106. In this randomised, placebo controlled double blind study, 60 people suffering from migraine were treated using constitutional homoeopathy over a period of 4 months. Those patients in the control group experienced a reduction in migraine frequency from 9.9 attacks per month to 7.9 per month, while those in the treatment group reduced their monthly attack rate from 10 to between 1.8 and 3 per month.

 

Homeopathy in Cuban epidemic neuropathy: an open clinical trial

Cairo J, Elliot BE, Barnouin J, Fleites P, Araoz A, Morales M, Verdura T, Sanchez M, Serrano C, Alvarez JL, Veillard JJ. British Homoeopathic Journal, 2001, 90, 150-157. In this uncontrolled trial, 15 people suffering from optic endemic neuropathy (group 1) and 16 people suffering from peripheral epidemic neuropathy (group 2) were given homeopathic Carbon sulph and homeopathic Tabacum for 30 days. The subjects were assessed for improvement in neurologic and ophthalmologic tests on commencement and again at 90 days after commencement of the trial. Those in group 1 experienced an averaged improvement of 73% and group 2 of 12.5%.

 

Using homeopathy for hypertension: a trial

 

Campistranous- Lavout JL., et al. Boletin Mexicano, 1999, 32, 42- 47. 68 people suffering from mild to moderate hypertension were enrolled in a double-blind randomised clinical trial comparing individualised homoeopathic therapy with placebo. Successful results were obtained with 82% of those using homoeopathy compared with 57% of those using placebo.

 

Retrospective study of homeopathic treatment of asthma

Castellsague API, Sturza CM. Retrospective Study in Asthma, Revista Homeopatica AMBH, 1998, 37, 5-21. In this multi-centre retrospective (uncontrolled) analysis, 196 people were treated for asthma with homoeopathy. Of the 196, 54 were claimed to have been cured and improvement was seen in a further 117.

 

Effects of homeopathic treatment on pruritus of haemodialysis patients: a randomised placebo-controlled double-blind trial

Cavalcanti AM, Rocha LM, Carillo R Jr, Lima LU, Lugon JR. Homeopathy. 2003 Oct;92(4):177-81. Pruritis, commonly experienced by those undergoing haemodialysis, was treated in 20 subjects under double-blind placebo-controlled randomised trial conditions comparing individualised homoeopathic treatment to placebo. Assessments were made at 15, 30, 45 and 60 days treatment, and after collating the results, researchers found that homoeopathic management reduced pruritis by 49%.

 

Homoeopathic treatment of mild traumatic brain injury

 

Chapman EH, Weintraub RJ, Milburn MA, Pirozzo TO, Woo E.. Journal of Head Trauma and Rehabilitation, 14, 6, December 1999, 521-42. In  a randomised, double blind, placebo controlled trial involving 60 subjects and a 4 month follow-up period, homoeopathy provided significant improvement in parameters using measures such as “Difficulty with Situations”, “Symptoms Rating Scale” and a “Participation in Daily Activities” scale.

 

Preliminary investigation into the effectiveness of the homoeopathic remedy, Ruta Graveolens in the treatment of pain in plantar fasciitis

Clark J, Percivall AA., British Journal of Podiatry, 2000, 3, 3, 81- 85. In a randomised double-blind trial, 14 people suffering from plantar fasciitis were given Ruta graveleons 30C or placebo. Those using the Ruta reported a greater level of pain relief than those using placebo.

 

Homeopathic treatment of hot flushes

 

Clover A, Ratsey D. British Homoeopathic Journal, 2002, 91, 75-79. Researchers at the Tunbridge Wells Homeopathic Hospital in the UK enrolled 31 female outpatients who had complained of menopausal flushes in this trial. They were treated using individualised homeopathic management and after their initial consultation and at least one follow-up, patients completed their own self-assessment rating of the treatment. 79% of the women enrolled in the study reported a reduction in both the severity and frequency of hot flushes as a result of the treatment.

 

Homeopathy and respiratory allergies: a series of 147 cases

 

Colin P. Homeopathy. 2006, Apr 95 (2):68-72. In this case series, 147 consecutive patients suffering from respiratory allergy who attended a private homeopathic clinic were assessed for their response to constitutional homeopathic treatment. Of these patients, 105 were sufferers of ear, nose and throat allergies. Only 2 of these patients failed to respond to treatment and none experienced an exacerbation of symptoms. The other 42 patients were sufferers of pulmonary allergies, all except 5 of whom experienced relief, with 2 of these experiencing an exacerbation of symptoms.

 

Homeopathic treatment of depression and anxiety

 

Davidson JRT, Morrison RM, Shore J, Davidson RT, Bedayn G. Alternative Therapies, 3, 1, January 1997, 46-49. In this trial, 12 subjects suffering from major depression, social phobia or panic disorder, were treated for 7 to 80 weeks with individually prescribed homoeopathic remedies and assessed on a clinical global improvement scale. (CGIS) or self-rated SCL-90 scale and the Social Phobia Scale (SPS). Subjects were given homoeopathic treatment either because they asked for it directly or because conventional treatment had been unsuccessful. The overall response rates for homoeopathy were 58% on the CGIS and 50% on the SCL-90 and SPS.

 

The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study

Derasse M, Klein P, Weiser M. Explore (NY). 2005 Jan;1(1):33-9. In this non-randomised observational study carried out in 38 Belgian clinics, 198 children suffering from acute febrile infections were assessed for their response to either acetaminophen or a combination of homeopathic medicines. The children had their infection symptoms, which included fever, cramps, disturbed sleep, crying, and difficulties eating or drinking, assessed and graded for a response to their respective medicines. After taking the results from all variables into account, it was found that the homeopathic combination was as effective as acetaminophen. The tolerance to medicines was also assessed as part of this trial and in this respect it was found that the homeopathic combination was superior to the acetaminophen.

 

 

 

Homoeopathic medicines in pregnancy and labour

Dorfman P, Lassere NM, Tetau M, , Cahiers de Biotherapie, 94, April 1987, 77-81. In this randomised double blind trial involving 93 women, a combination of homeopathic Caulophyllum, Actea racemosa, Arnica, Pulsatilla and Gelsemium, all in 5C potency, was used to determine its effect on the length of labour and complication rates. The medicine was used from the beginning of the ninth month of pregnancy, and reduced the average time of labour to 5.1 hours, in comparison to the placebo, the use of which was associated with an average labour time of 8.5 hours. The rate of complications for those using the homoeopathic combination was 11.3% while the complication rate under placebo was 40%.

 

Applicability of homoeopathic Caulophyllum Thalictroides during labour

Eid P, Felisi E, Sideri M , British Homoeopathic Journal, October, 1993, 82, 245-248. 22 women experiencing their first pregnancies were given homoeopathic Caulophyllum and their post-treatment deliveries compared to 34 labours retrospectively selected on the criteria used to select the test subjects. On analysis it was found that the women who were given the homoeopathic remedy had a reduction of the duration of labour by an average of 90 minutes.

 

Complementary treatment of varicose veins

Ernst E, Saradeth T, Resch KL, Phebology, 1990, 5, 157-163. Over a period of 24 days, the effects of a homoeopathic complex preparation and placebo on varicose veins were tested in a double-blind trial of 61 people suffering from this condition. The homoeopathic complex produced an averaged 44% improvement in the condition while those given the placebo experienced an averaged worsening of the disorder.

 

A controlled evaluation of a homeopathic preparation in the treatment of Influenza-like syndrome

Ferley JP, Zmirou D, D’Adhemar D, Balducci F. Br J Clin Pharmacol, 1989, Mar, 27, 3, 329-335. 487 people suffering from influenza were assigned to either Oscillococcinum (Anas barb.) 200CK or placebo, twice daily for 5 days. Significant results were achieved with the medicine over the placebo in all areas measured. This trial was repeated in 1998

 

Oscillococcinum homeopathic prescription in patients with Influenza-like Symptoms

Papp R, Schuback G, Beck E, Burkard, G, Bengel J, Lehrl S, Belon P. British Homeopathic Journal, April 1998, 87, pp69-76) with 372 people with the same results.

 

Effect of homeopathic treatment on fibrositis

Fisher P., Greenwood A, Huskisson EC, Turner P and Belon P. British Medical Journal, 5 August, 1989, 299, 365-366. Patients using Rhus Tox 6C three times daily in a double blind placebo controlled crossover trial found significant relief with the medicine over the placebo.

 

An experimental double-blind clinical trial method in homoeopathy: use of a limited range of remedies to treat fibrositis

Fisher P. British Homoeopathic Journal, 1986, July, 75, 3, 142-7. 24 subjects suffering from fibrositis were treated for the condition for 3 months with Arnica, Bryonia or Rhus tox, depending upon the similarity between the individuals’ symptoms and the clinical picture for the remedy. Using scores for pain, number of tender spots, and sleep quality to determine the response to the therapy, these remedies produced a statistically significant improvement, but only when the remedy was well indicated.

 

Snake remedies and eosinophilic granuloma complex in cats

Aboiutboul R.. Homeopathy, 2006 – January, 95, 1, 15-19. A veterinary clinic compiled case records involving Eosinophilic granuloma complex (EGC) in cats taken over an 8 year period. 20 cases of the condition were seen during this period and details of 15 of these cases were recorded. EGC is a syndrome characterised by lesions affecting the skin and the oral cavity. Conventional treatment is mainly symptomatic and may have undesirable side effects. In all 15 cases, reactions were mostly quick, leading to significant improvements, including complete recoveries.

 

Efficacy of two microdoses of a potentized homeopathic drug, Arsenicum Album, to ameliorate toxicity induced by repeated sublethal injections of arsenic trioxide in Mice. Pathobiology

Banerjee P, Bhattacharyya SS, Pathak S, Naoual B, Belon P, Khuda-Bukhsh AR. Comparative, 2008;75(3):156-70. This subject has had previous attention by Datta, Kundu and others, and in this randomised controlled trial, 6C and 30C homeopathic potencies of Arsenicum album (Arsenic trioxide) were given to mice prior to exposure to material doses of arsenic trioxide, as a means of determining whether or not the potentised Arsenicum album had any influence on the effects of arsenic. It was found that both the 6C and 30C potencies of Arsenicum album provided protection against the effects of arsenic trioxide, with the 30C providing a slightly better level of protection than the 6C.

 

Amelioration of carcinogen-induced toxicity in mice by administration of a potentized homeopathic drug, Natrum Sulphuricum 200CH

Bhattacharjee N, Pathak S, Khuda-Bukhsh AR. , Evid Based Complement Alternat Med. 2009, 6, 1, 65-75. Researchers at India’s University of Kalyani, expanding on work that had been previously been done in area, designed a trial to discover whether or not the homeopathic product, Nat sulph 200CH was able to protect mice against the effects of liver carcinogens, when compared to controls. Using various enzyme assays and other tests to determine the effects of the product, Nat sulph 200CH was found to reduce genomic and other carcinogenic effects as well as liver tumour formation caused by hepato-carcinogens, and to also increase the in-vivo levels of glutathione.

 

Evaluation of isopathic treatment of salmonella enteritidis in poultry

Berchieri A Jr, Turco WC, Paiva JB, et al. Homeopathy. 2006 Apr, 95, 2, 94-7. 180 chickens were divided into 4 groups. 2 of these groups were given pre-treatment with placebo and 2 were given different pre-treatment with preparations of a homeopathic nosode made from an antibiotic resistant strain of Salmonella enteric (Enteritidis) at a 30X potency, over a 10 day period. On day 17 the chickens were challenged with a culture of the same species of Salmonella from which the nosode was made. Cloacal swabs taken twice daily from the chickens at this point revealed that the birds that received the nosode showed a reduction in the growth of the bacteria compared to those given placebo.

 

Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium Majus, during induced hepatocarcinogenesis in mice

Biswas SJ, Khuda-Bukhsh AR. Indian Journal of Experimental Biology. 2004, Jul, 42, 7, 698-714. In this study, groups of mice were given substances that would normally be expected to induce the formation of liver cancer. At the same time, selected groups of these mice were given either homeopathic Chelidonium in 30C or 200C potencies or a placebo control. Both potencies of chelidonium provided a significant protective effect against the formation of liver cancers and favourably modulated some of the haematological markers normally associated with hepatotoxicity.

 

Efficacy of the potentized homeopathic drug, Carcinosin 200C, fed alone and in combination with another homeopathic drug, Chelidonium 200C, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice

Biswas SJ, Pathak S, Bhattacharjee N, Das JK, Khuda-Bukhsh AR. . J Altern Complement Med. 2005 Oct;11(5):839-54. Mice suffering from liver cancers were given either homeopathic Carcinosin 200C, or a combination of Carcinosn 200C and Chelidonium 200C. Compared to placebo, it was found that both of the homeopathic remedies were effective in ameliorating these cancers. In addition, they were both individually effective in protecting against the development of any further hepatocarcinogenesis and the combination of the 2 homeopathic medicines were slightly more so.

 

A study of the effects of decimal and centesimal homeopathic dilutions of arsenic on the retention and mobilisation of arsenic in rats

Cazin JC, Cazin M, Gaborit JL, et al. Human Toxicol, 1987, 6, 315-320. Radioactively labelled arsenious anhydride was administered to 60 rats. The rats were then given various homeopathic potencies (10X to 30X and 5C to 15C) of arsenicum album or a potentised water control. All of the potencies successfully increased the excretion rate of the radio-labelled arsenious anhydride when compared with the control, with the highest level of excretion being produced by the 14X and 7C potencies.

 

Effect of high dilutions of epidermal growth factor on in-vitro proliferation of keratinocyte and fibroblast cell lines

Fougeray S, Moubry K, Vallot N, Bastide M.. 6th Giri Symposium, Munich, Oct 1992, reported in British Homeopathic Journal, 93, 82. In this experiment, it was shown that 19X and 45X homeopathic potencies of Epidermal Growth Factor inhibited the proliferation of Keratinocyte and Fibroblast Cell Lines.

 

Effects of homoeopathic potencies: growth of saccharomyces cerevisiae in potentised copper sulphate dilutions

Fleisbach A, Fejfar V, Spranger J. British Homeopathic Journal, 2000, 89, Supplement 1, S65. Material concentrations of copper sulphate inhibit the growth of Saccharomyces cerevisiae and in this study, researchers determined what effect if any a homeopathic medicine made from copper sulphate would have on this organism. On exposure to homeopathically potentised copper sulphate, a potency dependant inhibition or enhancement of growth was seen.

Anti-oxidative, anti-proliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination

Gebhardt R, Arzneimittelforschung. 2003, 53, 12, 823-30. This laboratory study examined the effect of a homeopathic combination product and its separate components for anti-oxidative, anti-proliferative and biochemical effects on liver cells grown in laboratory tissue-culture. Protective effects against oxidation of the cells by tert-butyl hydroperoxide were shown by Carduus, China and Nux mosch, and the combination provided the same level of protection as these 3 individual remedies combined. Carduus, Chelidonium, Colocynthis and Veratrum alb all showed an antiproliferative effect against cell proliferation agents on the cells and the combination exhibited the same effect. Carduus and the combination both increased the conjugation effectiveness of glutathione.

 

 

Complement Ther Med. 2016 Apr;25:39-44. doi: 10.1016/j.ctim.2015.12.016. Epub 2016 Jan 4.

Comparison between the additive effects of diluted (rFSH) and diluted/dynamized (FSH 6 cH) recombinant follicle-stimulating hormone on the in vitro culture of ovine preantral follicles enclosed in ovarian tissue.Lima LF1, Rocha RM2, Alves AM2, Carvalho AA2, Chaves RN3, Lopes CA2, Báo SN4, Campello CC2, Rodrigues AP2, Figueiredo JR2.witzerland's national health insurance program.

 

Complement Ther Med. 2016 Apr;25:39-44. doi: 10.1016/j.ctim.2015.12.016. Epub 2016 Jan 4.

Comparison between the additive effects of diluted (rFSH) and diluted/dynamized (FSH 6 cH) recombinant follicle-stimulating hormone on the in vitro culture of ovine preantral follicles enclosed in ovarian tissue.

Lima LF1, Rocha RM2, Alves AM2, Carvalho AA2, Chaves RN3, Lopes CA2, Báo SN4, Campello CC2, Rodrigues AP2, Figueiredo JR2.

This study compared 2 types of recombinant follicle stimulating hormone (rFSH): diluted and diluted/dynamized, on in vitro development of ovine follicles.

In experiment 1, ovarian fragments were cultured for 1 or 7 days in α-MEM(+) in the absence or presence of different concentrations of diluted rFSH to determine the best concentration. In experiment 2, the effect of diluted and diluted/dynamized rFSH (rFSH 6 cH-ultradiluted and succussioned), alone or in combination, was studied.

In experiment 1, compared to control, 50ng/mL of diluted rFSH induced higher rates of follicular survival after 7 days of culture and higher percentages of growing follicles at day 1 of culture (P<0.05). In experiment 2, compared to control, diluted/dynamized rFSH induced higher follicular diameter and survival rate after 7 days and early follicle activation at day 1 of culture (P<0.05). Compared to diluted rFSH, diluted/dynamized rFSH induced higher rates of follicle activation at day 1 of culture (P<0.05).

In conclusion, compared to the control medium, diluted/dynamized rFSH promoted survival and early activation of follicles, while diluted rFSH promoted higher activation later in the culture. Thus, diluted/dynamized rFSH may be used as an alternative to diluted rFSH for the in vitro culture of ovine preantral follicles.

 

Homeopathy.2013 Oct; 102(4):274-82.

Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells.

Arora S1, Aggarwal A, Singla P, Jyoti S, Tandon S.

Homeopathy is controversial, due to the claims made for very high dilutions. Although several theories are proposed to understand the mechanisms of action, none are scientifically verified. This study aimed to investigate the efficacy of the selected homeopathic medicines in specific in vitro cancer models.

We assessed the cytotoxic activity of selected homeopathic medicines in mother tincture (MT), and ultramolecular dilution (30C, 200C, 1M and 10M) against cell lines deriving from tumors of particular organs, Sarsaparilla (Sars) on ACHN cells (human renal adenocarcinoma), Ruta graveolens (Ruta) on COLO-205 (human colorectal carcinoma), and Phytolacca decandra (Phyto) on MCF-7 (human breast carcinoma). Sars was also tested against Madin-Darby canine kidney (MDCK) cells (a non-malignant cell line). Cytotoxicity was measured using the 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) method, anti-proliferative activity by trypan blue exclusion assay, apoptosis determined by dual staining the cells with ethidium bromide (EB) and acridine orange (AO) dyes.

 

MTs and ultra-diluted preparations of the three homeopathic medicines had highly significant effects in the respective cancer cell lines, producing cytotoxicity and a decrease in cell proliferation. The effects were greatest with the MTs, but in all cases and persisted, although to a lesser degree in the ultra-diluted molecular preparations. Sars showed no effect on MDCK cells. In the homeopathic medicine treated cultures, hallmarks of apoptosis were evident including, cell shrinkage, chromatin condensation and DNA fragmentation.

This study provides preliminary laboratory evidence indicating the ability of homeopathic medicines as anticancer agents. Further studies of the action of these homeopathic remedies are warranted.

 

Homeopathic Research in Cancer

The modern academic and clinical medical research in the field of homeopathy is almost always based on the pathophysiological action of homeopathic ‘medicines’ on organs, tissues and  cells. A prospective observational study was conducted with cancer patients in two differently treated cohorts: one cohort with patients under complementary homeopathic treatment and one cohort with conventionally treated cancer patients. For a direct comparison, matched pairs with patients of the same tumour entity and comparable prognosis were to be formed. It was observed that improvement of quality of life as well as a decreased tendency of fatigue symptoms occurred in cancer patients under complementary homeopathic treatment.

Recent Academic Research in USA revealed that  ultra-diluted homeopathic remedies have cytotoxic effects on breast cancer cells. An in vitro study was conducted to determine if homeopathic products have any effect on breast cancer cell lines. Four ultra-diluted remedies  against two human breast adenocarcinoma cell lines and a cell line derived from immortalized normal human mammary epithelial cells were studied. The homeopathic remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. These effects were accompanied by altered expression of the cell cycle regulatory proteins, which were likely responsible for the cell cycle delay/arrest as well as induction of apoptosis. These findings demonstrated cytotoxic biological activity against cancer cells  of these homeopathic products at their ultra-diluted doses.

Ethanolic extract of Phytolacca decandra (PD), used in homeopathy for the treatment of various ailments such as chronic rheumatism, regular conjunctivitis, psoriasis, and in some skin diseases was tested for its possible anticancer potential. Cytotoxicity of the drug was tested on both normal (peripheral blood mononuclear cells) and A375 skin melanoma cancer cells. DNA fragmentation, changes in cellular morphology, apoptosis and necrosis, if any, were  recorded. Reactive oxygen species (ROS) accumulation, if any, and expression study of apoptotic genes also were evaluated to pin-point the actual events of apoptosis. Results showed that PD administration caused a remarkable reduction in proliferation of A375 cells, without showing cytotoxicity on peripheral blood mononuclear cells. Generation of ROS and DNA damage, which made the cancer cells prone to apoptosis, were found to be enhanced in PD-treated cells. Overall results demonstrate the anticancer potentials of Phytolacca decandra on A375 melanoma cells.

Homeopathic treatment efficiency was studied in patients with advanced gallbladder, periampullary, and liver carcinomas. The authors present  cases of various pathologically confirmed malignancies. These patients underwent homeopathic therapy as the primary cancer treatment. In the cases studied, conventional cancer treatments could not be initiated due to the advanced stage of their disease, poor general health performance status, and their financial constraints. This report indicated the clinical efficacy of homeopathic  therapy in treating those cancer patients.

Induction of apoptosis of tumour cells by some potentiated homeopathic drugs was  studied  concerning possible mechanism of action. Earlier studies indicated that homoeopathic medicines are cytotoxic to tumour cells and reduced animal tumours. Homeopathic remedies were tested for their ability to induce apoptosis. Similarly, the effect of homoeopathic medicines on apoptosis was measured by microarray analysis. Homeopathic remedies produced morphological changes in the Dalton's lymphoma ascites tumour cells and induced DNA laddering, increased apoptotic gene p53 and decreased antiapoptotic gene Bcl2. Administration of potentiated homoeopathic drugs to tumour-bearing mice induced increased apoptosis of tumour cells. Microarray analysis of cells treated with homoeopathic drugs indicated that many enzymes related to apoptosis were increased by homoeopathic drugs. These data indicate that apoptosis is one of the mechanisms of tumour reduction by homeopathic drugs. A comparison of potentiated drugs with their mother tincture indicated that the potentiated drugs have biological activity similar to that of their mother tincture in spite of ultradilution.

A study was conducted on the use of homeopathy in pediatric oncology in Germany. Homeopathy is a frequently used complementary and alternative medicine (CAM) treatment in Germany. Results were presented comparing responses of homeopathy users (HUs) and users of other forms of CAM (NHUs) in pediatric oncology (PO) in Germany. Differences between these two groups (usage, associated demographic characteristics, previous experience with CAM) were investigated. 186 (45.2%) of the 367 CAM users were exposed to homeopathy. The treatment duration amounted to a median of 601 days for HUs and 282 days for NHUs. Parents with p (127; 76.5%) also used homeopathy for their child's cancer. Nonmedical practitioners played a considerably greater role as source of information than did treating physicians. In the majority of patients HUs received their prescriptions from nonmedical practitioners (56%; 29.4% of NHUs). HUs communicate more frequently with their physicians about the CAM-use (77.7% versus 65.2%) and recommend CAM more often than NHUs (94% versus 85.6%). Homeopathy is the most frequently used CAM treatment in PO in Germany. HUs sustain treatment and therapies considerably longer than NHUs. Most families who had used homeopathy before their child was diagnosed with cancer also used homeopathy for the treatment of their child's cancer. Compared to other CAM treatments, patient satisfaction with homeopathy appears to be very high.

A tumour therapy with Amanita phalloides  for stabilization of B-cell chronic lymphatic leukemia was studied. In tumour cells, RNA polymerase II is more active than in other somatic cells. Amanita phalloides contains amanitin, inhibiting RNA polymerase II. Partial inhibition with amanitin influences tumour cell - but not normal cell - activity. To widen the treatment spectrum, homeopathic dilutions of Amanita phalloides, containing amanitin, were given to  patients with leukemia. Monitoring the leukemic cell count, different doses of amanitin were given. This homeopathic tumour therapy showed high potential to provide a gentle and essential medical treatment.

A clinical evaluation of a complex homeopathic injection therapy in the management of pain in patients after breast cancer treatment was performed. In breast cancer patients, post-treatment pain often appearing after several months and strongly impairing health-related quality of life. Conventional methods of pain reduction are often ineffective or even harmful. Injection therapy with a  complex homeopathic  medication with analgesic properties, used for treatment of the pain associated with trauma as well as with mediators of inflammation, was proposed as an innovative approach for pain relief after breast cancer treatment. After the last injection, all patients experienced a marked reduction of their level of pain on average from 7.6 +/- 1.5 to 2.4 +/- 1.4 points on a scale from 1 to 10 points. After a follow-up observational phase of 3 and 6 months, pain score ratings increased slightly again in some patients but remained consistently low in others. In any case, the ratings of pain levels did not reach the values assessed before the start of these injections. Similarly, health-related quality of life improved with this injection therapy. The perception of pain relief with homeopathic injections was high, reflecting an overall perceived positive outcome and tolerability of this treatment. This case series represents one more encouraging approach to using this complex homeopathic injection for pain relief in breast cancer patients.

According to modern classic pathology, epithelial-stromal interactions, mediated by the extracellular matrix, play a pivotal role in normal mammary gland function. It is now recognized that a specific environment is necessary for tumorigenesis; indeed, it has been postulated that cancer can be a physiological response to an abnormal stromal environment. An abnormal stroma can be regarded as a classical promoter in the terminology of carcinogenesis, in that the dysfunction of normal epithelial-mesenchymal interactions increases the probability that the pre-neoplastic lesion will progress to malignancy. On the other hand, in the terminology of development, the environment provided by the abnormal stroma may be considered 'permissive' for tumorigenesis by leading to the selection of cells with altered survival characteristics. These views signify that an aberrant stroma predisposes tissue to cancer by increasing the frequency with which an initiated cell proceeds to neoplasia, rather than by increasing the frequency of initiation. Importantly, normal stroma can efficiently inhibit the expression of neoplastic characteristics of tumour cells.

Conversely, perturbations in the epithelial-stromal interaction may accelerate the process of carcinogenesis, especially since carcinogen exposure elicits persistent phenotypic changes in stromal cells. These non-neoplastic stromal effects induced by carcinogens can be conducive to the expression of or to the progression of pre-neoplastic phenotypes, just as carcinoma-associated fibroblasts support malignant behaviours. Together these stromal alterations are likely to be essential to the development of frank neoplastic disease. These studies emphasize that the interactions between the epithelium and the stroma evolve dynamically, and thus will require considerable study if they are to be manipulated therapeutically.

Together, these recent studies underscore that the stromal-epithelial interface is a critical mediator of oncogenic potential. The heightened awareness of the stroma as an active participant in carcinogenesis has led to ideas for intervening in breast cancer progression by manipulating the stroma. Compared with the multiple routes taken by cells to become cancers, the response of tissues to cancer is relatively predictable. Controlling the early stages of invasive cancer growth may therefore be more readily achieved indirectly via the stroma.

So, the facts are not so simple; hunting the cancer cells only does not cover the whole story, moreover when toxic substances for the whole health economy are used, so that necessarily in each one cytotoxic chemical treatment a difficult dilemma always arises for both the physician and the patient: are the gains more than losses or the reverse and in what extent? In this dilemma at least the physician has to reply objectively and honestly, as he is bound both by medical jurisprudence and the Hippocratic Oath. Of course, any nontoxic therapy targeting to kill cancer cells, as the above mentioned cytotoxic action of homeopathic products on breast cancer cells, is certainly remarkable, impressive and promising for present and future research and clinical applications. But, Pathology itself is the Discipline that dictates directions for all of us, either conventional or ‘complementary’ therapists or researchers. Modern Pathology, considering also the principles  founded by Hippocrates and Virchow, dictates us, as above, to give priority not to the cancer cell itself only, but mainly on the integrity of the diseased tissue as a whole field and as it basically expressed by the balance between stroma and cancer cells. This is the battlefield according to both modern medical literature and of modern Holistic / Homeopathic Clinical Conception and, if we want to win, we have to adhere to it.

Certainly, conventional medicine has tried to make certain steps towards this direction, including the employment of factors inhibiting angiogenesis in the stroma of malignant tumours and, of course, this is encouraging for all, such as any conventional intervention through immune mechanisms, pathways, etc. affecting possibly cancer cells growth. From our side, the holistic in the wider sense, the homeopathic in the more specific and more familiar to me sense, a long, very long basic research, bio-theoretical approaches and clinical applications  have already offered a very rich and evidenced material ,absolutely accessibly to all the medical community, despite the hard persecutions of many pioneers in the field and their followers in many countries all over the world, unfortunately certain of them included in our European family. An example of relevant holistic /homeopathic application is Homotoxicology, a Pathology-based Homeopathic approach, which was developed certain decades ago by Dr Reckeweg in Germany. Homotoxicology deals with the structural and functional stages that an organ or tissue passes successively from mild reactive disorders, such as acute inflammations and allergies to the most dangerous ones, namely the degenerative ,the autoimmune and, finally, Cancer. According to this systematic pathogenetic chain investigation, any tissue pathology, like Cancer, first starts in the stroma and then is extended in the cells, so that the most suitable strategy is to target first of all to the stroma through appropriate homeopathic remedies’ combinations.